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In the New England Journal of Medicine, Garvey and colleagues [5] report the results of the REDEFINE 1 trial, a 68-week, phase 3a double-blind, placebo-controlled and active-controlled trial evaluating the efficacy and safety of coadministered cagrilintide and semaglutide in adults with obesity [body mass index (BMI) ≥ 30 kg/m 2 ] or overweight (BMI ≥ 27 kg/m 2 ) with at least one weight-related comorbidity